We completed the first phase of a study to evaluate the quality of the DNA in the HAAS samples that was extracted in 1994 for Apolipoprotein E genotyping. The DNA quality could be used reliably for very robust PCR analyses. We then proceeded ato extract new DNA from the remaining buffy coat in a nested case control study that includes all cases of dementia identified in exams 4 and 5, cases of mild cognitive impairment (defined as a drop in CASI score of >4pts per year), a random set of controls frequency matched in 5-year strata to the cases. In the second stage, we are conducting association studies of polymorphisms for inflammation in relation to the risk for dementia. In line with the research objective of investigating the association of inflammation to the risk of dementia.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG007270-05
Application #
6969760
Study Section
(EDBP)
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2004
Total Cost
Indirect Cost
Name
Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Petrovitch, Helen; Ross, G Webster; He, Qimei et al. (2008) Characterization of Japanese-American men with a single neocortical AD lesion type. Neurobiol Aging 29:1448-55
Launer, Lenore J; Petrovitch, Helen; Ross, G Webster et al. (2008) AD brain pathology: vascular origins? Results from the HAAS autopsy study. Neurobiol Aging 29:1587-90
Marlowe, Lauren; Peila, Rita; Benke, Kelly Suzanne et al. (2006) Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk. Neurodegener Dis 3:320-6
Yucesoy, Berran; Peila, Rita; White, Lon R et al. (2006) Association of interleukin-1 gene polymorphisms with dementia in a community-based sample: the Honolulu-Asia Aging Study. Neurobiol Aging 27:211-7
Korf, Esther S C; White, Lon R; Scheltens, Ph et al. (2006) Brain aging in very old men with type 2 diabetes: the Honolulu-Asia Aging Study. Diabetes Care 29:2268-74
Irie, Fumiko; Strozyk, D; Peila, R et al. (2006) Brain lesions on MRI and endogenous sex hormones in elderly men. Neurobiol Aging 27:1137-44
Scher, Ann I; Terwindt, Gisela M; Verschuren, W M Monique et al. (2006) Migraine and MTHFR C677T genotype in a population-based sample. Ann Neurol 59:372-5
Kruit, Mark C; Launer, Lenore J; Ferrari, Michel D et al. (2006) Brain stem and cerebellar hyperintense lesions in migraine. Stroke 37:1109-12
Eiriksdottir, Gudny; Aspelund, Thor; Bjarnadottir, Kristjana et al. (2006) Apolipoprotein E genotype and statins affect CRP levels through independent and different mechanisms: AGES-Reykjavik Study. Atherosclerosis 186:222-4
Scher, A I; Terwindt, G M; Picavet, H S J et al. (2005) Cardiovascular risk factors and migraine: the GEM population-based study. Neurology 64:614-20

Showing the most recent 10 out of 35 publications