Abstract

Our nested case control study includes all cases of dementia identified in exams 4 and 5 of the Honolulu Asia Aging Study, cases of mild cognitive impairment (defined as a drop in CASI score of >4pts per year), a random set of controls frequency matched in 5-year strata to the cases. We are currently conducting association studies of polymorphisms for inflammation and vascular disease in relation to the risk for dementia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG007270-06
Application #
7135628
Study Section
(EDBP)
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2005
Total Cost
Indirect Cost

  Institution

Name
Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Petrovitch, Helen; Ross, G Webster; He, Qimei et al. (2008) Characterization of Japanese-American men with a single neocortical AD lesion type. Neurobiol Aging 29:1448-55
Launer, Lenore J; Petrovitch, Helen; Ross, G Webster et al. (2008) AD brain pathology: vascular origins? Results from the HAAS autopsy study. Neurobiol Aging 29:1587-90
Scher, Ann I; Terwindt, Gisela M; Verschuren, W M Monique et al. (2006) Migraine and MTHFR C677T genotype in a population-based sample. Ann Neurol 59:372-5
Kruit, Mark C; Launer, Lenore J; Ferrari, Michel D et al. (2006) Brain stem and cerebellar hyperintense lesions in migraine. Stroke 37:1109-12
Eiriksdottir, Gudny; Aspelund, Thor; Bjarnadottir, Kristjana et al. (2006) Apolipoprotein E genotype and statins affect CRP levels through independent and different mechanisms: AGES-Reykjavik Study. Atherosclerosis 186:222-4
Marlowe, Lauren; Peila, Rita; Benke, Kelly Suzanne et al. (2006) Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk. Neurodegener Dis 3:320-6
Yucesoy, Berran; Peila, Rita; White, Lon R et al. (2006) Association of interleukin-1 gene polymorphisms with dementia in a community-based sample: the Honolulu-Asia Aging Study. Neurobiol Aging 27:211-7
Korf, Esther S C; White, Lon R; Scheltens, Ph et al. (2006) Brain aging in very old men with type 2 diabetes: the Honolulu-Asia Aging Study. Diabetes Care 29:2268-74
Irie, Fumiko; Strozyk, D; Peila, R et al. (2006) Brain lesions on MRI and endogenous sex hormones in elderly men. Neurobiol Aging 27:1137-44
Scher, A I; Terwindt, G M; Picavet, H S J et al. (2005) Cardiovascular risk factors and migraine: the GEM population-based study. Neurology 64:614-20

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