Abstract

Improved vaccines against influenza would enhance our ability to decrease the deleterious effects of epidemics. This study aims to develop genetic vaccination strategies against influenza. DNA and adenoviral vaccines have been developed against different strains of influenza, including the H5N1 avian flu, and testing has been initiated to determine the optimal strategies for immunization.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI005003-05
Application #
7299806
Study Section
(VIC)
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2006
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Nabel, Gary J (2013) Designing tomorrow's vaccines. N Engl J Med 368:551-60
Yang, Zhi-Yong; Wei, Chih-Jen; Kong, Wing-Pui et al. (2007) Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity. Science 317:825-8
Kong, Wing-Pui; Hood, Chantelle; Yang, Zhi-Yong et al. (2006) Protective immunity to lethal challenge of the 1918 pandemic influenza virus by vaccination. Proc Natl Acad Sci U S A 103:15987-91
Epstein, Suzanne L; Kong, Wing-pui; Misplon, Julia A et al. (2005) Protection against multiple influenza A subtypes by vaccination with highly conserved nucleoprotein. Vaccine 23:5404-10