Improved vaccines against influenza would enhance our ability to decrease the deleterious effects of epidemics. This study aims to develop genetic vaccination strategies against influenza. DNA and adenoviral vaccines have been developed against different strains of influenza, including the H5N1 avian flu, and testing has been initiated to determine the optimal strategies for immunization. Several DNA vaccine candidates showed promising results and one avian influenza vaccine is being tested through the VRC Clinical Trials Core.
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| Yang, Zhi-Yong; Wei, Chih-Jen; Kong, Wing-Pui et al. (2007) Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity. Science 317:825-8 |
| Kong, Wing-Pui; Hood, Chantelle; Yang, Zhi-Yong et al. (2006) Protective immunity to lethal challenge of the 1918 pandemic influenza virus by vaccination. Proc Natl Acad Sci U S A 103:15987-91 |
| Epstein, Suzanne L; Kong, Wing-pui; Misplon, Julia A et al. (2005) Protection against multiple influenza A subtypes by vaccination with highly conserved nucleoprotein. Vaccine 23:5404-10 |
