During the past year, investigators at the VRC have determined a relationship between the Copper Metabolism gene Murr1 domain (COMMD)proteins, which are strong inhibitors of NF-B (nuclear factor B)mediated transcription, and the stability of host proteins important for restricting HIV-1 replication. The data generated by these results have provided an improved understanding of HIV viral-host interactions and the role of the Murr1 family of proteins in regulating cellular and viral gene expression.
| Frymoyer, Adam; Verotta, Davide; Jacobson, Pamala et al. (2013) Population pharmacokinetics of unbound mycophenolic acid in adult allogeneic haematopoietic cell transplantation: effect of pharmacogenetic factors. Br J Clin Pharmacol 75:463-75 |
| Ganesh, Lakshmanan; Yoshimoto, Takanobu; Moorthy, Narayani C et al. (2006) Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis. Mol Cell Biol 26:3864-74 |
