The function and biological activities of the HIV-1 Viral Protein R (Vpr)are being studied at the molecular and cellular levels. During the past year, the laboratory identified a cellular complex to which Vpr binds, and it was determined that this complex plays an essential role in Vpr's biological activities. These findings will be used as a basis for further T cells experiments in the context of viral infection, especially with regard to HIV-1 induced cell death and as a potentially therapeutic target.
| Frymoyer, Adam; Verotta, Davide; Jacobson, Pamala et al. (2013) Population pharmacokinetics of unbound mycophenolic acid in adult allogeneic haematopoietic cell transplantation: effect of pharmacogenetic factors. Br J Clin Pharmacol 75:463-75 |
| Ganesh, Lakshmanan; Yoshimoto, Takanobu; Moorthy, Narayani C et al. (2006) Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis. Mol Cell Biol 26:3864-74 |
