Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC007354-03
Application #
2463725
Study Section
Special Emphasis Panel (LMC)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Sun, Haiying; Nikolovska-Coleska, Zaneta; Chen, Jianyong et al. (2005) Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics. Bioorg Med Chem Lett 15:793-7
Koehler, Niklas K U; Yang, Chao-Yie; Varady, Judith et al. (2004) Structure-based discovery of nonpeptidic small organic compounds to block the T cell response to myelin basic protein. J Med Chem 47:4989-97
Sun, Haiying; Nikolovska-Coleska, Zaneta; Yang, Chao-Yie et al. (2004) Structure-based design of potent, conformationally constrained Smac mimetics. J Am Chem Soc 126:16686-7
Nikolovska-Coleska, Zaneta; Wang, Renxiao; Fang, Xueliang et al. (2004) Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization. Anal Biochem 332:261-73
Krajewski, Krzysztof; Marchand, Christophe; Long, Ya-Qiu et al. (2004) Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin. Bioorg Med Chem Lett 14:5595-8
Sun, Haiying; Nikolovska-Coleska, Zaneta; Yang, Chao-Yie et al. (2004) Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site. J Med Chem 47:4147-50
Nikolovska-Coleska, Zaneta; Xu, Liang; Hu, Zengjian et al. (2004) Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem 47:2430-40
Song, Yan-Li; Roller, Peter P; Long, Ya-Qiu (2004) Development of l-3-aminotyrosine suitably protected for the synthesis of a novel nonphosphorylated hexapeptide with low-nanomolar Grb2-SH2 domain-binding affinity. Bioorg Med Chem Lett 14:3205-8
Li, Peng; Peach, Megan L; Zhang, Manchao et al. (2003) Structure-based design of thioether-bridged cyclic phosphopeptides binding to Grb2-SH2 domain. Bioorg Med Chem Lett 13:895-9
Krajewski, Krzysztof; Long, Ya-Qiu; Marchand, Christophe et al. (2003) Design and synthesis of dimeric HIV-1 integrase inhibitory peptides. Bioorg Med Chem Lett 13:3203-5

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