Helicobacter pylori, a Gram-negative bacterium, is responsible for one of one of the most common bacterial infections, affecting about 50% of the human population. H. pylori was first discovered in 1982, and subsequently found to be the causative agent of gastritis, gastric and duodenal ulcers, and gastric cancer. The World Health Organization classified H. pylori as a Group 1 carcinogen. We initiated the H. pylori project to study the transcription regulation in pathogenesis. Specifically, we will focus on the study of the transcription machinery and on the regulation of virulence gene expression, both in vivo and in vitro.

Agency
National Institute of Health (NIH)
Institute
Division of Basic Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010633-02
Application #
7291914
Study Section
(GRCB)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2005
Total Cost
Indirect Cost
Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Jin, Ding Jun; Mata Martin, Carmen; Sun, Zhe et al. (2017) Nucleolus-like compartmentalization of the transcription machinery in fast-growing bacterial cells. Crit Rev Biochem Mol Biol 52:96-106