Helicobacter pylori, a Gram-negative bacterium, is responsible for one of one of the most common bacterial infections, affecting about 50% of the human population. H. pylori was first discovered in 1982, and subsequently found to be a major causative agent of gastritis, gastric and duodenal ulcers, and gastric cancer. The World Health Organization classified H. pylori as a Group 1 carcinogen. We initiated the H. pylori project to study the transcriptional regulation in the pathogenesis of the bacterium. Specifically, we will focus on 1) the study of the transcription machinery and on the regulation of virulence gene expression in vivo; and 2) the development of an in vitro transcription assay system, which currently is not available in the field.

Agency
National Institute of Health (NIH)
Institute
Division of Basic Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010633-03
Application #
7338702
Study Section
(GRCB)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2006
Total Cost
Indirect Cost
Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Jin, Ding Jun; Mata Martin, Carmen; Sun, Zhe et al. (2017) Nucleolus-like compartmentalization of the transcription machinery in fast-growing bacterial cells. Crit Rev Biochem Mol Biol 52:96-106