Abstract

The Molecular Technologies section supports intramural clinical trial efforts by brining on molecular platforms such as the reverse phase tissue lysate array. Drs. Satoshi Nishizuka and Carolyn Best will develop technologies and implement them for intramural trials of high priority. The team will also work on new technological developments. Drs. Nishizuka and Best have developed a validation protocol for the use of the TLA in clinical trial biopsy material. A new arrayer is due to arrive in fall, 2005 and validation will proceed on this machine.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Basic Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010643-02
Application #
7291923
Study Section
(MTP)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2005
Total Cost
Indirect Cost

  Institution

Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Major, Sylvia M; Nishizuka, Satoshi; Morita, Daisaku et al. (2006) AbMiner: a bioinformatic resource on available monoclonal antibodies and corresponding gene identifiers for genomic, proteomic, and immunologic studies. BMC Bioinformatics 7:192
So, Kanji; Tamura, Gen; Honda, Teiichiro et al. (2006) Multiple tumor suppressor genes are increasingly methylated with age in non-neoplastic gastric epithelia. Cancer Sci 97:1155-8
So, Kanji; Tamura, Gen; Honda, Teiichiro et al. (2006) Quantitative assessment of RUNX3 methylation in neoplastic and non-neoplastic gastric epithelia using a DNA microarray. Pathol Int 56:571-5
Nishizuka, Satoshi; Washburn, Newell R; Munson, Peter J (2006) Evaluation method of ordinary flatbed scanners for quantitative density analysis. Biotechniques 40:442, 444, 446 passim
Rudelius, Martina; Pittaluga, Stefania; Nishizuka, Satoshi et al. (2006) Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma. Blood 108:1668-76
Homma, Naoyuki; Tamura, Gen; Honda, Teiichiro et al. (2006) Spreading of methylation within RUNX3 CpG island in gastric cancer. Cancer Sci 97:51-6
Nishizuka, Satoshi (2006) Profiling cancer stem cells using protein array technology. Eur J Cancer 42:1273-82
Bussey, Kimberly J; Chin, Koei; Lababidi, Samir et al. (2006) Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel. Mol Cancer Ther 5:853-67
Honda, Teiichiro; Tamura, Gen; Endoh, Yasushi et al. (2005) Expression of tumor suppressor and tumor-related proteins in differentiated carcinoma, undifferentiated carcinoma with tubular component and pure undifferentiated carcinoma of the stomach. Jpn J Clin Oncol 35:580-6