Broadly reactive antitumor cytotoxic cell responses, generated in vitro by mouse splenocytes cultured with the lymphokine IL2, are modulated in a strain-dependent fashion by addition of polyinosinic acid (Poly I) to the cultures. Although Poly I is a synthetic polynucleotide, macromolecular polyanionic carbohydrates, some of which occur naturally in man, have been identified which act like Poly I. Studies of mouse strains whose splenocytes generate only low levels of antitumor cytotoxicity with Poly I, show that suppressive cell-cell interactions contribute to the low responses.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Biology And Diagnosis (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CB005003-20
Application #
4691748
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
20
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Cancer Biology and Diagnosis
Department
Type
DUNS #
City
State
Country
United States
Zip Code