Antibodies reacting with human ovarian cancer cells have been coupled to Pseudomonas toxin. Such immunotoxins kill ovarian cells in tissue culture and human ovarian cancer cells growing in the peritoneal cavity of nude mice. A number of monoclonal antibodies reacting with human ovarian cancer cells have been isolated by the hybridoma technique. Phase I studies have been begun to treat adult T-cell leuklemia with an antibody to the Il2 receptor conjugated to Pseudomonas exotoxin.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Biology And Diagnosis (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CB008753-04
Application #
3963048
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Cancer Biology and Diagnosis
Department
Type
DUNS #
City
State
Country
United States
Zip Code