Many factors may alter pharmacokinetics, including cytochrome P450 phenotype, malnutrition, intestinal parasites, drug source (manufacturer), and drug storage conditions. In this study, in vitro assays of drug bioavailability will be performed using antiretroviral agents produced in several different countries. Pharmacokinetic profiles of several standard regimens will be assessed in several distinct geographic regions. If profiles are substantially different, studies will be performed to assess the cause, and whether dosage regimens different from those recommended in the US might be appropriate to maximize efficacy and safety.
| Penzak, S R; Kabuye, G; Mugyenyi, P et al. (2007) Cytochrome P450 2B6 (CYP2B6) G516T influences nevirapine plasma concentrations in HIV-infected patients in Uganda. HIV Med 8:86-91 |
| Penzak, Scott R; Acosta, Edward P; Turner, Michele et al. (2004) Antiretroviral drug content in products from developing countries. Clin Infect Dis 38:1317-9 |
| Penzak, Scott R; Acosta, Edward P; Turner, Michele et al. (2003) Analysis of generic nevirapine products in developing countries. JAMA 289:2648-9 |
