This work intends to achieve the synthesis of 5-azacytosine-containing DNA fragments which are designed as specific inhibitors of DNA methyl transferase. After genome insertion, the relationship between the location of the 5-azacytosine residue and the base sequence of the oligomer is expected to confer the resulting molecule sufficient selectivity to allow activation of those specific genes for which DNA methylation is inhibited.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CM006175-01
Application #
3963222
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Cancer Treatment
Department
Type
DUNS #
City
State
Country
United States
Zip Code