The unexpectedly high percentage of aqueous extracts of marine organisms and terrestrial plants which exhibited AIDS-antiviral activity in the primary screen necessitated an investigation of recurring classes of antiviral agents and methods to differentiate such compounds from more unique anti-HIV compounds which might also be present. A series of simple experiments to test for known classes of AIDS-antiviral compounds, and to provide general chemical characterization of the anti-HIV compounds present, has been developed. The NCI in vitro primary antitumor screen, in conjunction with computerized pattern-recognition (e.g., Compare) algorithms, are also being explored as a dereplication approach for cytotoxic extracts.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CM007327-01
Application #
3838165
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Division of Cancer Treatment
Department
Type
DUNS #
City
State
Country
United States
Zip Code