Abstract

People infected with HIV are at increased risk of cancer, due to AIDS-related immunosuppression, infections with other oncogenic viruses, and other exposures, such as tobacco and alcohol. This project inlcudes studies to examine cancer risk in HIV-infected persons and characterize risk factors for these infections. The project includes studies focusing on Kaposi sarcoma, non-Hodgkin lymphoma, and cervical cancer (the three AIDS-defining cancers), as well as lung cancer, liver cancer, anal cancer, and Hodgkin lymphoma. The project also includes studies of cancer cofactors of importance to people with HIV/AIDS, including human herpesvirus 8, the causative agent of Kaposi sarcoma. Several studies evaluate cancer risk in Africa, a region heavily affected by the HIV/AIDS epidemic.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP010150-06
Application #
7288889
Study Section
(VEB)
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2005
Total Cost
Indirect Cost

  Institution

Name
Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Suneja, Gita; Shiels, Meredith S; Melville, Sharon K et al. (2013) Disparities in the treatment and outcomes of lung cancer among HIV-infected individuals. AIDS 27:459-68
Simard, Edgar P; Shiels, Meredith S; Bhatia, Kishor et al. (2012) Long-term cancer risk among people diagnosed with AIDS during childhood. Cancer Epidemiol Biomarkers Prev 21:148-54
Bhatia, Kishor; Shiels, Meredith S; Berg, Alexandra et al. (2012) Sarcomas other than Kaposi sarcoma occurring in immunodeficiency: interpretations from a systematic literature review. Curr Opin Oncol 24:537-46
Simard, Edgar P; Pfeiffer, Ruth M; Engels, Eric A (2012) Mortality due to cancer among people with AIDS: a novel approach using registry-linkage data and population attributable risk methods. AIDS 26:1311-8
Persson, E Christina; Shiels, Meredith S; Dawsey, Sanford M et al. (2012) Increased risk of stomach and esophageal malignancies in people with AIDS. Gastroenterology 143:943-950.e2
Gadalla, S M; Preiss, L R; Eyster, M E et al. (2011) Correlates of high hepatitis C virus RNA load in a cohort of HIV-negative and HIV-positive individuals with haemophilia. J Viral Hepat 18:161-9
Engels, Eric A (2010) Epidemiology of thymoma and associated malignancies. J Thorac Oncol 5:S260-5
Shiels, Meredith S; Goedert, James J; Moore, Richard D et al. (2010) Reduced risk of prostate cancer in U.S. Men with AIDS. Cancer Epidemiol Biomarkers Prev 19:2910-5
Shebl, Fatma M; Bhatia, Kishor; Engels, Eric A (2010) Salivary gland and nasopharyngeal cancers in individuals with acquired immunodeficiency syndrome in United States. Int J Cancer 126:2503-8
Lanoy, E; Engels, E A (2010) Skin cancers associated with autoimmune conditions among elderly adults. Br J Cancer 103:112-4

Showing the most recent 10 out of 50 publications