Abstract

People infected with HIV are at increased risk of cancer, due to AIDS-related immunosuppression, infections with other oncogenic viruses, and other exposures, such as tobacco and alcohol. This project inlcudes studies to examine cancer risk in HIV-infected persons and characterize risk factors for these infections. Likewise, recipients of solid organ transplants have an increased risk of cancer, due to immunosuppression induced by medications given to prevent organ rejection. This project includes epidemiological studies of cancer in transplant recipients. Two cancers of interest in these populations and others are non-Hodgkin lymphoma and lung cancer, both of which may be related to infections, inflammation, or immune dysfunction.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP010150-07
Application #
7330803
Study Section
(VEB)
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2006
Total Cost
Indirect Cost

  Institution

Name
Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Suneja, Gita; Shiels, Meredith S; Melville, Sharon K et al. (2013) Disparities in the treatment and outcomes of lung cancer among HIV-infected individuals. AIDS 27:459-68
Simard, Edgar P; Shiels, Meredith S; Bhatia, Kishor et al. (2012) Long-term cancer risk among people diagnosed with AIDS during childhood. Cancer Epidemiol Biomarkers Prev 21:148-54
Bhatia, Kishor; Shiels, Meredith S; Berg, Alexandra et al. (2012) Sarcomas other than Kaposi sarcoma occurring in immunodeficiency: interpretations from a systematic literature review. Curr Opin Oncol 24:537-46
Simard, Edgar P; Pfeiffer, Ruth M; Engels, Eric A (2012) Mortality due to cancer among people with AIDS: a novel approach using registry-linkage data and population attributable risk methods. AIDS 26:1311-8
Persson, E Christina; Shiels, Meredith S; Dawsey, Sanford M et al. (2012) Increased risk of stomach and esophageal malignancies in people with AIDS. Gastroenterology 143:943-950.e2
Gadalla, S M; Preiss, L R; Eyster, M E et al. (2011) Correlates of high hepatitis C virus RNA load in a cohort of HIV-negative and HIV-positive individuals with haemophilia. J Viral Hepat 18:161-9
Engels, Eric A (2010) Epidemiology of thymoma and associated malignancies. J Thorac Oncol 5:S260-5
Shiels, Meredith S; Goedert, James J; Moore, Richard D et al. (2010) Reduced risk of prostate cancer in U.S. Men with AIDS. Cancer Epidemiol Biomarkers Prev 19:2910-5
Shebl, Fatma M; Bhatia, Kishor; Engels, Eric A (2010) Salivary gland and nasopharyngeal cancers in individuals with acquired immunodeficiency syndrome in United States. Int J Cancer 126:2503-8
Lanoy, E; Engels, E A (2010) Skin cancers associated with autoimmune conditions among elderly adults. Br J Cancer 103:112-4

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