Abstract

The NCI is carrying out a major evaluation of selected screening procedures for the early detection of prostate, lung, colon, and ovarian cancer (The PLCO Trial). The Trial will include 74,000 screening arm participants (37,000 men, 37,000 women; age 55-74) and an equal number of non-screened controls. Questionnaire data and biologic samples are collected in this population for use in studies on the etiology of cancer and related diseases and for the evaluation of early markers of cancer development. Within the Trial, etiologic studies for specific cancers and related conditions will be phased in as sufficient numbers of cases accrue. Currently, we are evaluating genetic and environmental (including lifestyle-related) determinants of risk for adenomatous polyps, to identify causes of the early changes in the pathologic sequence leading to colorectal cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP010152-01
Application #
6420470
Study Section
(LPG)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Luhn, Patricia; Dallal, Cher M; Weiss, Jocelyn M et al. (2013) Circulating adipokine levels and endometrial cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev 22:1304-12
Koutros, Stella; Meyer, Tamra E; Fox, Stephen D et al. (2013) Prospective evaluation of serum sarcosine and risk of prostate cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Carcinogenesis 34:2281-5
Tsai, Huei-Ting; Cross, Amanda J; Graubard, Barry I et al. (2010) Dietary factors and risk of chronic lymphocytic leukemia and small lymphocytic lymphoma: a pooled analysis of two prospective studies. Cancer Epidemiol Biomarkers Prev 19:2680-4
Yeager, Meredith; Chatterjee, Nilanjan; Ciampa, Julia et al. (2009) Identification of a new prostate cancer susceptibility locus on chromosome 8q24. Nat Genet 41:1055-7
Schenk, Jeannette M; Riboli, Elio; Chatterjee, Nilanjan et al. (2009) Serum retinol and prostate cancer risk: a nested case-control study in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev 18:1227-31
Lettre, Guillaume; Jackson, Anne U; Gieger, Christian et al. (2008) Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet 40:584-91
Freedman, D Michal; Chang, Shih-Chen; Falk, Roni T et al. (2008) Serum levels of vitamin D metabolites and breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev 17:889-94
Huang, Wen-Yi; Berndt, Sonja I; Kang, Daehee et al. (2006) Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk. Cancer Epidemiol Biomarkers Prev 15:306-11
Rodriguez Ortner, Elizabeth; Hayes, Richard B; Weissfeld, Joel et al. (2006) Effect of homeodomain protein NKX3.1 R52C polymorphism on prostate gland size. Urology 67:311-5
Ji, Bu-Tian; Weissfeld, Joel L; Chow, Wong-Ho et al. (2006) Tobacco smoking and colorectal hyperplastic and adenomatous polyps. Cancer Epidemiol Biomarkers Prev 15:897-901

Showing the most recent 10 out of 14 publications