Abstract

To date, we have developed a comprehensive lung tissue microarray that included 300 NSCLC cases and 183 neuroendocrine tumors. We have engaged in a systematical evaluation of candidate protein markers for lung cancer diagnosis and prognosis. In a recent study, we showed that one of the core chromosome remodeling factors, BRM is a prognostic factor in NSCLC. Recently, we have collaborated with Dr. Phil Denis's group to show that AKT activation by phosporylation has prognostic value in lung cancers. In addition, our work with Dr. Curt Harris' group also helped identify that carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors. Using this unique resource, we have developed a comprehensive protein expression profile for lung cancer and a we are completing a searchable database, LPGImage, to allow our results be readily accessed via the internet. Currently, we are exploring the use of these arrays for genetic and gene expression analysis. We anticipate that this unique resource will lead to many fruitful discoveries with researchers both inside and outside of NCI.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP010164-06
Application #
7330821
Study Section
(LPG)
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2006
Total Cost
Indirect Cost

  Institution

Name
Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Gill, R K; Yang, S-H; Meerzaman, D et al. (2011) Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer. Oncogene 30:3784-91
Ozbudak, Irem H; Shilo, Konstantin; Tavora, Fabio et al. (2009) Glucose transporter-1 in pulmonary neuroendocrine carcinomas: expression and survival analysis. Mod Pathol 22:633-8
Fukuoka, Junya; Dracheva, Tatiana; Shih, Joanna H et al. (2007) Desmoglein 3 as a prognostic factor in lung cancer. Hum Pathol 38:276-83
Hong, Kyeong-Man; Yang, Sei-Hoon; Chowdhuri, Sinchita Roy et al. (2007) Inactivation of LLC1 gene in nonsmall cell lung cancer. Int J Cancer 120:2353-8
Dracheva, Tatiana; Philip, Reena; Xiao, Wenming et al. (2007) Distinguishing lung tumours from normal lung based on a small set of genes. Lung Cancer 55:157-64
Tsurutani, Junji; Fukuoka, Junya; Tsurutani, Hiroko et al. (2006) Evaluation of two phosphorylation sites improves the prognostic significance of Akt activation in non-small-cell lung cancer tumors. J Clin Oncol 24:306-14
He, Ping; Varticovski, Lyuba; Bowman, Elise D et al. (2004) Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray. Hum Pathol 35:1196-209
Krop, Ian; Player, Audrey; Tablante, Ana et al. (2004) Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types. Mol Cancer Res 2:489-94
Fukuoka, Junya; Fujii, Takeshi; Shih, Joanna H et al. (2004) Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer. Clin Cancer Res 10:4314-24
Player, Audrey; Gillespie, John; Fujii, Takeshi et al. (2003) Identification of TDE2 gene and its expression in non-small cell lung cancer. Int J Cancer 107:238-43