Abstract

Statistical models for genetics data are often surprisingly challenging, and often require advanced and new statistical methods. This project continues to investigate a number of such areas, including, for example: (1) a global analysis in Drosophila melanogaster adult transcription between the sexes using a 31,464 element FlyGEM microarray to determine what fraction of the genome shows sex-biased expression, what tissues express these genes, the predicted functions of these genes, and where these genes map onto the genome; (2) a genetic analysis of the myositis syndromes as they relate to silicone implants, using a matched case control study in women of the HLA DQA1*0102 and HLA DRB1*0301 allele rates, and coupled with clinical, serologic and immunogenetics features; (3) a study asking genomic level questions about the structure of protein coding coding exons with a special emphasis on very large internal exons.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Center for Information Technology (CIT)
Type
Intramural Research (Z01)
Project #
1Z01CT000268-07
Application #
7145143
Study Section
(MSCL)
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2005
Total Cost
Indirect Cost

  Institution

Name
Computer Research and Technology
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Konig, I R; Malley, J D; Weimar, C et al. (2007) Practical experiences on the necessity of external validation. Stat Med 26:5499-511
O'Hanlon, Terrance P; Carrick, Danielle Mercatante; Targoff, Ira N et al. (2006) Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies. Medicine (Baltimore) 85:111-27
Gupta, Vaijayanti; Parisi, Michael; Sturgill, David et al. (2006) Global analysis of X-chromosome dosage compensation. J Biol 5:3
Stojanov, Silvia; Hoffmann, Florian; Kery, Anja et al. (2006) Cytokine profile in PFAPA syndrome suggests continuous inflammation and reduced anti-inflammatory response. Eur Cytokine Netw 17:90-7
O'Hanlon, Terrance P; Rider, Lisa G; Mamyrova, Gulnara et al. (2006) HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodies. Arthritis Rheum 54:3670-81
Mamyrova, Gulnara; O'Hanlon, Terrance P; Monroe, Jason B et al. (2006) Immunogenetic risk and protective factors for juvenile dermatomyositis in Caucasians. Arthritis Rheum 54:3979-87
O'Hanlon, Terrance P; Carrick, Danielle Mercatante; Arnett, Frank C et al. (2005) Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1 and -DQA1 allelic profiles and motifs define clinicopathologic groups in caucasians. Medicine (Baltimore) 84:338-49
Parisi, Michael; Nuttall, Rachel; Edwards, Pamela et al. (2004) A survey of ovary-, testis-, and soma-biased gene expression in Drosophila melanogaster adults. Genome Biol 5:R40
O'Hanlon, Terrance; Koneru, Bhanu; Bayat, Elham et al. (2004) Immunogenetic differences between Caucasian women with and those without silicone implants in whom myositis develops. Arthritis Rheum 50:3646-50
Jerebko, Anna K; Summers, Ronald M; Malley, James D et al. (2003) Computer-assisted detection of colonic polyps with CT colonography using neural networks and binary classification trees. Med Phys 30:52-60

Showing the most recent 10 out of 24 publications