Abstract

We are characterizing the CNS phenotypes caused by elevated mtDNA mutation levels and relating these findings to age-related functional changes. Furthermore, we will investigate the affects of ischemic brain injury in these same mice. We have already documented change in cortical thickness and lamination patterns. There are also changes in oxidative energy production and mitochondrial function. These changes parallel cognitive and motor deficiencies in the mtDNA mutators. Drugs that upregulate mitochondrial function are being evaluated.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Intramural Research (Z01)
Project #
1Z01DA000517-02
Application #
7733847
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2008
Total Cost
$645,828
Indirect Cost

  Institution

Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

McIntosh, Scot; Howell, Leonard; Hemby, Scott E (2013) Dopaminergic dysregulation in prefrontal cortex of rhesus monkeys following cocaine self-administration. Front Psychiatry 4:88
Kimmel, Heather L; Nye, Jonathon A; Voll, Ronald et al. (2012) Simultaneous measurement of extracellular dopamine and dopamine transporter occupancy by cocaine analogs in squirrel monkeys. Synapse 66:501-8
Manvich, Daniel F; Kimmel, Heather L; Cooper, Debra A et al. (2012) The serotonin 2C receptor antagonist SB 242084 exhibits abuse-related effects typical of stimulants in squirrel monkeys. J Pharmacol Exp Ther 342:761-9
Murnane, Kevin Sean; Perrine, Shane Alan; Finton, Brendan James et al. (2012) Effects of exposure to amphetamine derivatives on passive avoidance performance and the central levels of monoamines and their metabolites in mice: correlations between behavior and neurochemistry. Psychopharmacology (Berl) 220:495-508
Bauzo, Rayna M; Kimmel, Heather L; Howell, Leonard L (2012) The cystine-glutamate transporter enhancer N-acetyl-L-cysteine attenuates cocaine-induced changes in striatal dopamine but not self-administration in squirrel monkeys. Pharmacol Biochem Behav 101:288-96
Andersen, Monica L; Sawyer, Eileen K; Carroll, F Ivy et al. (2012) Influence of chronic dopamine transporter inhibition by RTI-336 on motor behavior, sleep, and hormone levels in rhesus monkeys. Exp Clin Psychopharmacol 20:77-83
Murnane, K S; Kimmel, H L; Rice, K C et al. (2012) The neuropharmacology of prolactin secretion elicited by 3,4-methylenedioxymethamphetamine (""ecstasy""): a concurrent microdialysis and plasma analysis study. Horm Behav 61:181-90
Manvich, Daniel F; Kimmel, Heather L; Howell, Leonard L (2012) Effects of serotonin 2C receptor agonists on the behavioral and neurochemical effects of cocaine in squirrel monkeys. J Pharmacol Exp Ther 341:424-34
Andersen, Monica L; Sawyer, Eileen K; Howell, Leonard L (2012) Contributions of neuroimaging to understanding sex differences in cocaine abuse. Exp Clin Psychopharmacol 20:2-15
Howell, Leonard Lee; Murnane, Kevin Sean (2011) Nonhuman primate positron emission tomography neuroimaging in drug abuse research. J Pharmacol Exp Ther 337:324-34

Showing the most recent 10 out of 26 publications