GPR40 is a seven transmembrane receptor that is expressed in a great number of tissues including the pancreatic islet cells, brain and gastrointestinal tract. The ligand stimulating this receptor is felt to be medium chain fatty acids. During the past year we have succeeded in creating mice with homozygous deletion of the majority of the coding exon for the GPR40 gene and expressing the enhanced form of the green fluorescent protein as a fusion protein following the first 15 amino acids of GPR40.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Intramural Research (Z01)
Project #
1Z01DK069082-02
Application #
7153585
Study Section
(DDB)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2005
Total Cost
Indirect Cost
Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Li, Ai-Jun; Wiater, Michael F; Wang, Qing et al. (2016) Deletion of GPR40 fatty acid receptor gene in mice blocks mercaptoacetate-induced feeding. Am J Physiol Regul Integr Comp Physiol 310:R968-74