We have employed two genome technologies in Saccharomyces cerevisiae to determine the cellular impact and possible mechanisms involved in arsenic toxicity and carcinogenicity. By combining transcript profiling with the screening of a comprehensive panel of bar-coded mutant strains, we have identified the genes and pathways most affected by this metalloid.
| Wielgus, Albert R; Chignell, Colin F; Miller, David S et al. (2007) Phototoxicity in human retinal pigment epithelial cells promoted by hypericin, a component of St. John's wort. Photochem Photobiol 83:706-13 |
| Bammler, Theodore; Beyer, Richard P; Bhattacharya, Sanchita et al. (2005) Standardizing global gene expression analysis between laboratories and across platforms. Nat Methods 2:351-6 |
| Haugen, Astrid C; Kelley, Ryan; Collins, Jennifer B et al. (2004) Integrating phenotypic and expression profiles to map arsenic-response networks. Genome Biol 5:R95 |
| Karthikeyan, Gopalakrishnan; Santos, Janine H; Graziewicz, Maria A et al. (2003) Reduction in frataxin causes progressive accumulation of mitochondrial damage. Hum Mol Genet 12:3331-42 |
| Waters, Michael; Boorman, Gary; Bushel, Pierre et al. (2003) Systems toxicology and the Chemical Effects in Biological Systems (CEBS) knowledge base. EHP Toxicogenomics 111:15-28 |
