Given the magnitude and complexity of the wide array of medical, laboratory, imaging, and genotypic data collected on these participants, data cleaning activities have taken longer than originally expected. Phenotype annotation is basically complete. An initial panel of candidate genes have been run. Several international collaborative groups have been formed with the focus of examining a variety of multi-phenotype analyses. Several analyses have been completed, with papers in preparation. ? ? A follow-up examination on a subset of the AGES cohort is planned.? ? For more information on the study, see www.hjarta.is/english/ages ? ? See also Z01 AG007380 (Dr. Tarris)

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Intramural Research (Z01)
Project #
1Z01EY000401-06
Application #
7594077
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2007
Total Cost
$151,442
Indirect Cost
Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Thorsteinsdottir, Ingunn; Aspelund, Thor; Gudmundsson, Elias et al. (2016) High-Sensitivity Cardiac Troponin I Is a Strong Predictor of Cardiovascular Events and Mortality in the AGES-Reykjavik Community-Based Cohort of Older Individuals. Clin Chem 62:623-30
Steingrimsdottir, Laufey; Halldorsson, Thorhallur I; Siggeirsdottir, Kristin et al. (2014) Hip fractures and bone mineral density in the elderly--importance of serum 25-hydroxyvitamin D. PLoS One 9:e91122
Jonasson, Fridbert; Arnarsson, Arsaell; EirĂ­ksdottir, Gudny et al. (2011) Prevalence of age-related macular degeneration in old persons: Age, Gene/environment Susceptibility Reykjavik Study. Ophthalmology 118:825-30
Ikram, M Kamran; Sim, Xueling; Xueling, Sim et al. (2010) Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. PLoS Genet 6:e1001184
Qiu, Chengxuan; Cotch, Mary Frances; Sigurdsson, Sigurdur et al. (2009) Microvascular lesions in the brain and retina: The age, gene/environment susceptibility-Reykjavik study. Ann Neurol 65:569-76
Qiu, Chengxuan; Cotch, Mary Frances; Sigurdsson, Sigurdur et al. (2008) Retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-Reykjavik study. Diabetes 57:1645-50
Harris, Tamara B; Launer, Lenore J; Eiriksdottir, Gudny et al. (2007) Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics. Am J Epidemiol 165:1076-87