The objectives of this project are: (1) to characterize developmental patterns from daily measurements of gonadotropins and for estrogens in premenarchial girls and pubescent boys based on radioimmunoassay methods for measuring urinary luteinizing hormone, urinary follicle stimulating hormone, and urinary estradiol, estriol and estrone hormones; (2) gonadotropins in both castrated and intact male monkeys of different ages; (3) growth hormone in normal and precocious pubertal children; (4) to assess circadian and other rhythms in heart rate, temperature and other serial data collected from long-term studies in humans; and (5) to perform analysis of these serial measurements using methods of statistical time series analysis, including autoregressive filtering, auto- and cross-spectrum analysis, and robust smoothing procedures.

Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1990
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code