Information on a measure related to obesity was obtained on over 3000 Amish individuals. Segregation analysis has been done on the trait with the best fitting model being an autosomal dominant model adjusted for age and sex effects. The model has been used to identify 20 families that are informative for linkage analysis. Additional phenotyping of obesity related traits has been funded by the German Government. Genotyping is currently being done at the Center for Inherited Disease Research. Markers will be used in an attempt to identify genetic components for traits related to obesity in the Amish. - obesity, Old- Order Amish, linkage analysis, genomic screening - Human Subjects

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Intramural Research (Z01)
Project #
1Z01HG000103-04
Application #
6433654
Study Section
(IDRB)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Human Genome Research
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Platte, P; Papanicolaou, G J; Johnston, J et al. (2003) A study of linkage and association of body mass index in the Old Order Amish. Am J Med Genet C Semin Med Genet 121C:71-80