This project was begun in this fiscal year. It involves collection of clinical information and blood samples forgenotyping in highly inbred families in Syria from families with many members affected with cleft lip and palate. Cooperation with Syrian local investigators and a month long visit to Syria by Dr. Wyszynski haveresulted in collection of several large pedigrees suitable for linkage analysis by the technique of homozygositymapping. Genotyping is due to begin shortly on these invaluable samples.
| Marazita, Mary L; Murray, Jeffrey C; Lidral, Andrew C et al. (2004) Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35. Am J Hum Genet 75:161-73 |
| Wyszynski, Diego F; Albacha-Hejazi, Hasan; Aldirani, Mohammed et al. (2003) A genome-wide scan for loci predisposing to non-syndromic cleft lip with or without cleft palate in two large Syrian families. Am J Med Genet A 123A:140-7 |
| Zeiger, Joanna S; Hetmanski, Jacqueline B; Beaty, Terri H et al. (2003) Evidence for linkage of nonsyndromic cleft lip with or without cleft palate to a region on chromosome 2. Eur J Hum Genet 11:835-9 |
