This project was begun in the previous fiscal year. It involves collection of clinical information and blood samples for genotyping in highly inbred families in Syria from families with many members affected with cleft lip and palate. Cooperation with Syrian local investigators and a month long visit to Syria by Dr. Wyszynski have resulted in collection of over 20 large pedigrees suitable for linkage analysis by the technique of homozygosity mapping. Data collection is ongoing. A 10 cM homozygosity mapping genome scan has been completed with no positive results. A collaboration with Dr. Terri Beaty of JHUSPH has been initiated to increase power. Our samples from Syria will be genotyped at CIDR along with Dr. Beaty?s samples from several other sites and collaborative linkage analyses will be performed during the upcoming fiscal year.
| Marazita, Mary L; Murray, Jeffrey C; Lidral, Andrew C et al. (2004) Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35. Am J Hum Genet 75:161-73 |
| Wyszynski, Diego F; Albacha-Hejazi, Hasan; Aldirani, Mohammed et al. (2003) A genome-wide scan for loci predisposing to non-syndromic cleft lip with or without cleft palate in two large Syrian families. Am J Med Genet A 123A:140-7 |
| Zeiger, Joanna S; Hetmanski, Jacqueline B; Beaty, Terri H et al. (2003) Evidence for linkage of nonsyndromic cleft lip with or without cleft palate to a region on chromosome 2. Eur J Hum Genet 11:835-9 |
