Abstract

Dr. Miller has collected a large series of families with idiopathic scoliosis. An application for access to genotyping has been made to the NIH/JHU Center for Inherited Disease Research. Preliminary statistical genetic analysis are underway in an effort to determine whether genetic components are responsible, at least in part, for the variation in lateral curvature of the spine and/or in the expression of clinically significant scoliosis. Data is available on approximately 1200individuals in 200 families. Genotyping has been approved by theCenter for Inherited Disease Research. - scoliosis, genetic linkage analysis, quantitative trait, genomic screen, - Human Subjects

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Intramural Research (Z01)
Project #
1Z01HG000125-03
Application #
6433671
Study Section
(IDRB)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
Human Genome Research
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Miller, Nancy H; Justice, Cristina M; Marosy, Beth et al. (2005) Identification of candidate regions for familial idiopathic scoliosis. Spine (Phila Pa 1976) 30:1181-7
Justice, Cristina M; Miller, Nancy H; Marosy, Beth et al. (2003) Familial idiopathic scoliosis: evidence of an X-linked susceptibility locus. Spine (Phila Pa 1976) 28:589-94