This project to study the genetics of Inflammatory Bowel Disease(IBD) was initiated in this fiscal year in collaboration withDrs. Steven Brant and Theodore Bayliss of Johns HopkinsUniversity School of Medicine and with the International IBDConsortium. An international consortium of investigators who havepreviously published genome wide linkage screens for IBD wasformed and all members agreed to genotype the same markers in twocandidate regions on at least 50 highly families with bothparents and two or more affected children available forgenotyping. These data were then deposited into a common databaseat the University of Canberra, anonymized and then distributed tothe participating groups. Each group performed its own analysesof these data and presented them at a workshop in Australia inSeptember. Additional genotyping is ongoing and a manuscript isin preparation. Dr. Bailey-Wilson has been named head of theAnalysis committee for this consortium and will continue tointeract with Drs. Brant, Bayliss and the IBD Consortium onfuture analyses of the genetics of IBD. - Inflammatory bowel disease, Crohn's disease, ulcerative colitis, genetics, IBD Consortium - Human Subjects

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Intramural Research (Z01)
Project #
1Z01HG000151-01
Application #
6227988
Study Section
Special Emphasis Panel (IDRB)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
National Human Genome Research Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Karban, Amir S; Okazaki, Toshihiko; Panhuysen, Carolien I M et al. (2004) Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. Hum Mol Genet 13:35-45
Brant, S R; Panhuysen, C I; Bailey-Wilson, J E et al. (2000) Linkage heterogeneity for the IBD1 locus in Crohn's disease pedigrees by disease onset and severity. Gastroenterology 119:1483-90