ULTRA-FAST MRI FOR CARDIOVASCULAR APPLICATIONS Realtime interventional MRI techniques continue to be improved through the development of new imaging methods and pre-clinical implementation of procedures. We have implemented a reduced field of view projection reconstruction technique and a self gated technique which is a development along the way to wireless gating. The imaging techniques have been demonstrated in MRI guided endovasucalar repair of aortic aneurysm. We have also implemented a novel efficient method for the separation of fat and water signals with steady state free precession imaging, and we have demonstrated myocardial tagging in a single heartbeat. Both developments will prove useful when imaging function in realtime during the application of therapy, or for realtime stress testing.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Intramural Research (Z01)
Project #
1Z01HL004608-06
Application #
7158613
Study Section
Cancer Etiology Study Section (CE)
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2005
Total Cost
Indirect Cost
Name
U.S. National Heart Lung and Blood Inst
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Nezafat, Reza; Thompson, Richard B; Derbyshire, J Andrew et al. (2006) Partial field-of-view spiral phase-contrast imaging using complex difference processing. Magn Reson Med 56:676-80
Kellman, Peter; McVeigh, Elliot R (2006) Phased array ghost elimination. NMR Biomed 19:352-61
Raval, Amish N; Karmarkar, Parag V; Guttman, Michael A et al. (2006) Real-time magnetic resonance imaging-guided endovascular recanalization of chronic total arterial occlusion in a swine model. Circulation 113:1101-7
Raval, Amish N; Karmarkar, Parag V; Guttman, Michael A et al. (2006) Real-time MRI guided atrial septal puncture and balloon septostomy in swine. Catheter Cardiovasc Interv 67:637-43
Kellman, Peter; Larson, Andrew C; Hsu, Li-Yueh et al. (2005) Motion-corrected free-breathing delayed enhancement imaging of myocardial infarction. Magn Reson Med 53:194-200
Helm, Patrick A; Tseng, Hsiang-Jer; Younes, Laurent et al. (2005) Ex vivo 3D diffusion tensor imaging and quantification of cardiac laminar structure. Magn Reson Med 54:850-9
Derbyshire, J A; Herzka, D A; McVeigh, E R (2005) S5FP: spectrally selective suppression with steady state free precession. Magn Reson Med 54:918-28
Kellman, Peter; Chung, Yiu-Cho; Simonetti, Orlando P et al. (2005) Multi-contrast delayed enhancement provides improved contrast between myocardial infarction and blood pool. J Magn Reson Imaging 22:605-13
Thompson, Richard B; Aviles, Ronnier J; Faranesh, Anthony Z et al. (2005) Measurement of skeletal muscle perfusion during postischemic reactive hyperemia using contrast-enhanced MRI with a step-input function. Magn Reson Med 54:289-98
Kellman, Peter; McVeigh, Elliot R (2005) Image reconstruction in SNR units: a general method for SNR measurement. Magn Reson Med 54:1439-47

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