ULTRA-FAST MRI FOR CARDIOVASCULAR APPLICATIONS Over the past year we have further developed the ability of MRI systems to image interventional procedures in real-time. We have implemented real-time PR, and real-time FISP imaging sequences and incorporated custom reconstruction software with the vendor supplied scan plane control software. Real-time control of numerous scanning parameters such as saturation pulses, coil gains, and field shims have been incorporated into the system. Two monitors are available in the scan room for the physician, and two keyboard controls are available at the end of the scanning table. We have now begun a series of animal experiments demonstrating real-time guidance of injection catheters in the left ventricle. We have demonstrated the visualization of needle deployment and injection of contrast agent directly into the myocardium These results will have direct impact on the delivery of therapeutic agents directly into tissues.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Intramural Research (Z01)
Project #
1Z01HL004608-02
Application #
6541716
Study Section
Cancer Etiology Study Section (CE)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2001
Total Cost
Indirect Cost
Name
U.S. National Heart Lung and Blood Inst
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Nezafat, Reza; Thompson, Richard B; Derbyshire, J Andrew et al. (2006) Partial field-of-view spiral phase-contrast imaging using complex difference processing. Magn Reson Med 56:676-80
Kellman, Peter; McVeigh, Elliot R (2006) Phased array ghost elimination. NMR Biomed 19:352-61
Raval, Amish N; Karmarkar, Parag V; Guttman, Michael A et al. (2006) Real-time magnetic resonance imaging-guided endovascular recanalization of chronic total arterial occlusion in a swine model. Circulation 113:1101-7
Raval, Amish N; Karmarkar, Parag V; Guttman, Michael A et al. (2006) Real-time MRI guided atrial septal puncture and balloon septostomy in swine. Catheter Cardiovasc Interv 67:637-43
McVeigh, Elliot R; Guttman, Michael A; Kellman, Peter et al. (2005) Real-time, Interactive MRI for cardiovascular interventions. Acad Radiol 12:1121-7
Shechter, Guy; Resar, Jon R; McVeigh, Elliot R (2005) Rest period duration of the coronary arteries: implications for magnetic resonance coronary angiography. Med Phys 32:255-62
Herzka, Daniel A; Derbyshire, J Andrew; Kellman, Peter et al. (2005) Single heartbeat cardiac tagging for the evaluation of transient phenomena. Magn Reson Med 54:1455-64
Nezafat, Reza; Kellman, Peter; Derbyshire, J Andrew et al. (2005) Real-time blood flow imaging using autocalibrated spiral sensitivity encoding. Magn Reson Med 54:1557-61
Ennis, Daniel B; Kindlman, Gordon; Rodriguez, Ignacio et al. (2005) Visualization of tensor fields using superquadric glyphs. Magn Reson Med 53:169-76
Larson, Andrew C; Kellman, Peter; Arai, Andrew et al. (2005) Preliminary investigation of respiratory self-gating for free-breathing segmented cine MRI. Magn Reson Med 53:159-68

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