The Information Engineering Branch is responsible for developing and deploying all the production resources at NCBI. These include GenBank, Entrez, PubMed, BLAST, RefSeq, UniGene, PubMed Central, NCBI Bookshelf, LocusLink, annotation and assembly of complete genomes, and the NCBI software toolkit, among other things. These activities are closely interconnected and often data or personel from one activity are involved in others as well. These activities are a combination of research and development, and use expertise from biology and medicine, as well as from computer science and mathematics. NCBI production resources are widely used by more than 340,000 unique users a day, at a peak rate of about 1400 web hits a second. Users bulk download more than 1.4 terabytes of data a day. This project provides many of the most heavily used public resources in biomedicine in the world.
| Pruitt, Kevin; Zinn, Rebekah L; Ohm, Joyce E et al. (2006) Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet 2:e40 |
| Lapolla, John S; Schultz, Ted R; Kjer, Karl M et al. (2006) Phylogenetic position of the ant genus Acropyga Roger (Hymenoptera: Formicidae) and the evolution of trophophoresy. Insect Syst Evol 37:197-212 |
| Fyfe, John C; Menotti-Raymond, Marilyn; David, Victor A et al. (2006) An approximately 140-kb deletion associated with feline spinal muscular atrophy implies an essential LIX1 function for motor neuron survival. Genome Res 16:1084-90 |
| Benson, Dennis A; Karsch-Mizrachi, Ilene; Lipman, David J et al. (2006) GenBank. Nucleic Acids Res 34:D16-20 |
| Hu, Zhi-Liang; Dracheva, Svetlana; Jang, Wonhee et al. (2005) A QTL resource and comparison tool for pigs: PigQTLDB. Mamm Genome 16:792-800 |
| Zaitlen, Noah A; Kang, Hyun Min; Feolo, Michael L et al. (2005) Inference and analysis of haplotypes from combined genotyping studies deposited in dbSNP. Genome Res 15:1594-600 |
| Altschul, Stephen F; Wootton, John C; Gertz, E Michael et al. (2005) Protein database searches using compositionally adjusted substitution matrices. FEBS J 272:5101-9 |
| Benson, Dennis A; Karsch-Mizrachi, Ilene; Lipman, David J et al. (2005) GenBank. Nucleic Acids Res 33:D34-8 |
| Pruitt, Kim D; Tatusova, Tatiana; Maglott, Donna R (2005) NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins. Nucleic Acids Res 33:D501-4 |
| Maglott, Donna; Ostell, Jim; Pruitt, Kim D et al. (2005) Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res 33:D54-8 |
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