Abstract

The Information Engineering Branch is responsible for developing and deploying all the production resources at NCBI. These include GenBank, Entrez, PubMed, BLAST, RefSeq, UniGene, PubMed Central, NCBI Bookshelf, LocusLink, annotation and assembly of complete genomes, and the NCBI software toolkit, among other things. These activities are closely interconnected and often data or personel from one activity are involved in others as well. These activities are a combination of research and development, and use expertise from biology and medicine, as well as from computer science and mathematics. NCBI production resources are widely used by more than 1.8 million unique users a day, at a peak rate of about 3200 web hits a second. Users bulk download more than 1.5 terabytes of data a day. This project provides many of the most heavily used public resources in biomedicine in the world.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Library of Medicine (NLM)
Type
Intramural Research (Z01)
Project #
1Z01LM000160-05
Application #
7316273
Study Section
(IEB)
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2006
Total Cost
Indirect Cost

  Institution

Name
National Library of Medicine
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Benson, Dennis A; Karsch-Mizrachi, Ilene; Lipman, David J et al. (2006) GenBank. Nucleic Acids Res 34:D16-20
Pruitt, Kevin; Zinn, Rebekah L; Ohm, Joyce E et al. (2006) Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet 2:e40
Lapolla, John S; Schultz, Ted R; Kjer, Karl M et al. (2006) Phylogenetic position of the ant genus Acropyga Roger (Hymenoptera: Formicidae) and the evolution of trophophoresy. Insect Syst Evol 37:197-212
Fyfe, John C; Menotti-Raymond, Marilyn; David, Victor A et al. (2006) An approximately 140-kb deletion associated with feline spinal muscular atrophy implies an essential LIX1 function for motor neuron survival. Genome Res 16:1084-90
Murphy, William J; Agarwala, Richa; Schaffer, Alejandro A et al. (2005) A rhesus macaque radiation hybrid map and comparative analysis with the human genome. Genomics 86:383-95
Knutsen, Turid; Gobu, Vasuki; Knaus, Rodger et al. (2005) The interactive online SKY/M-FISH & CGH database and the Entrez cancer chromosomes search database: linkage of chromosomal aberrations with the genome sequence. Genes Chromosomes Cancer 44:52-64
Ostell, James (2005) Databases of Discovery. ACM Queue 3:40-48
Hu, Zhi-Liang; Dracheva, Svetlana; Jang, Wonhee et al. (2005) A QTL resource and comparison tool for pigs: PigQTLDB. Mamm Genome 16:792-800
Zaitlen, Noah A; Kang, Hyun Min; Feolo, Michael L et al. (2005) Inference and analysis of haplotypes from combined genotyping studies deposited in dbSNP. Genome Res 15:1594-600
Altschul, Stephen F; Wootton, John C; Gertz, E Michael et al. (2005) Protein database searches using compositionally adjusted substitution matrices. FEBS J 272:5101-9

Showing the most recent 10 out of 39 publications