a) Lithium stimulates ACTH secretion by anterior pituitary cells in culture. Lithium, phorbol esters, high extracellular calcium, and diacylglycerol comprise a distinct class of agents affecting ACTH secretion through mechanisms involving phospholipases, inositide metabolism, and protein kinase C. b) The enzyme which transfers long chain fatty acids from acyl coenzyme A to rhodopsin has been solubilized and partially purified. This reaction is prototypical of a new class of posttranslational modification of membrane proteins, including receptors.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH000429-06
Application #
4696338
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1985
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code