The foundations of risk for many psychiatric disorders, including those with adult onset, are increasingly understood as arising from anomalies of neurodevelopment. In this longitudinal study (with participants returning at approximately two-year intervals) we combine brain imaging information with extensive behavioral and neuropsychological testing as well as genetic data to explore the relationship between genes, brain, and behavior in typical and atypical development. Understanding the typical path of brain development is imperative to assess whether illness are associated with deviations from that path. To this end we have acquired the worlds largest data set of well-characterized longitudinal pediatric brain MRI scans (N = 1000). This data serves as a resource for many neuroimaging projects throughout the world and has led to key insights into the biology of adolescent emotion, cognition, and behavior. To assess nature/nurture questions we are studying brain development in mono and dizygotic twins. The study of subjects with variations in the number of X and Y chromosomes (i.e. XXY, XXX, XYY, XXXXY) and subjects with hormone anomalies (i.e. Cushings disease, Congenital Adrenal Hyperplasia, Familial Precocious Puberty) allow us to discern the relative contributions of hormones and chromosomes to male/female differences in the brain. Clinical populations investigated include the largest imaging studies of ADHD and Childhood-Onset Schizophrenia. Seminal contributions to the literature have been produced in each of these areas.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002794-06
Application #
7594544
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2007
Total Cost
$3,239,626
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Lenroot, Rhoshel K; Schmitt, James E; Ordaz, Sarah J et al. (2009) Differences in genetic and environmental influences on the human cerebral cortex associated with development during childhood and adolescence. Hum Brain Mapp 30:163-74
Wallace, Gregory L; Happe, Francesca; Giedd, Jay N (2009) A case study of a multiply talented savant with an autism spectrum disorder: neuropsychological functioning and brain morphometry. Philos Trans R Soc Lond B Biol Sci 364:1425-32
Lenroot, Rhoshel K; Gogtay, Nitin; Greenstein, Deanna K et al. (2007) Sexual dimorphism of brain developmental trajectories during childhood and adolescence. Neuroimage 36:1065-73
Shaw, Philip; Gornick, Michele; Lerch, Jason et al. (2007) Polymorphisms of the dopamine D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 64:921-31
Shaw, Philip; Lerch, Jason P; Pruessner, Jens C et al. (2007) Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study. Lancet Neurol 6:494-500
Mackie, Susan; Shaw, Philip; Lenroot, Rhoshel et al. (2007) Cerebellar development and clinical outcome in attention deficit hyperactivity disorder. Am J Psychiatry 164:647-55
Shaw, P; Eckstrand, K; Sharp, W et al. (2007) Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proc Natl Acad Sci U S A 104:19649-54
Nugent 3rd, Tom F; Herman, David H; Ordonez, Anna et al. (2007) Dynamic mapping of hippocampal development in childhood onset schizophrenia. Schizophr Res 90:62-70
Giedd, Jay N; Clasen, Liv S; Wallace, Gregory L et al. (2007) XXY (Klinefelter syndrome): a pediatric quantitative brain magnetic resonance imaging case-control study. Pediatrics 119:e232-40
Giedd, Jay N; Schmitt, James Eric; Neale, Michael C (2007) Structural brain magnetic resonance imaging of pediatric twins. Hum Brain Mapp 28:474-81

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