Abstract

Examples of our findings include:? 1) We evaluated in healthy subjects a promising radioligand to quantify the cannabinoid CB1 (marijuana) receptor in brain. This receptor may be altered in obesity and alcoholism? ? 2) We studied in healthy subjects a promising probe to measure inflammation. In the coming year, we will examine disorders with inflammation in brain, including AIDS and Alzheimers disease.? ? 3) We studied a cAMP enzyme involved in intracellular signaling that may be involved with depression. We completed stuidies in healthy subejcst and will study patients with depression in the coming year.? ? 4) We have just begun studies in healthy subjects and patients with Alzheimers disease of a radioligand to measure amyloid. Amyloidis a protein that accumulates ijn brain and kills nerve cells.? ? 5) We recently completed a study in patients with panic disorder of a probe for the NK1 receptor. This novel receptor is a target for medication treatment in anxiety disorders.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002852-03
Application #
7594581
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2007
Total Cost
$1,886,245
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Lohith, Talakad G; Zoghbi, Sami S; Morse, Cheryl L et al. (2014) Retest imaging of [11C]NOP-1A binding to nociceptin/orphanin FQ peptide (NOP) receptors in the brain of healthy humans. Neuroimage 87:89-95
Hirvonen, J; Zanotti-Fregonara, P; Umhau, J C et al. (2013) Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography. Mol Psychiatry 18:916-21
Kannan, Pavitra; Pike, Victor W; Halldin, Christer et al. (2013) Factors that limit positron emission tomography imaging of p-glycoprotein density at the blood-brain barrier. Mol Pharm 10:2222-9
Bosker, Wendy M; Karschner, Erin L; Lee, Dayong et al. (2013) Psychomotor function in chronic daily Cannabis smokers during sustained abstinence. PLoS One 8:e53127
Kimura, Yasuyuki; Siméon, Fabrice G; Zoghbi, Sami S et al. (2012) Quantification of metabotropic glutamate subtype 5 receptors in the brain by an equilibrium method using 18F-SP203. Neuroimage 59:2124-30
Hirvonen, Jussi; Kreisl, William C; Fujita, Masahiro et al. (2012) Increased in vivo expression of an inflammatory marker in temporal lobe epilepsy. J Nucl Med 53:234-40
Kannan, Pavitra; Brimacombe, Kyle R; Kreisl, William C et al. (2011) Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET. Proc Natl Acad Sci U S A 108:2593-8
Kannan, Pavitra; Telu, Sanjay; Shukla, Suneet et al. (2011) The ""specific"" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2). ACS Chem Neurosci 2:82-9
Kimura, Yasuyuki; Siméon, Fabrice G; Hatazawa, Jun et al. (2010) Biodistribution and radiation dosimetry of a positron emission tomographic ligand, 18F-SP203, to image metabotropic glutamate subtype 5 receptors in humans. Eur J Nucl Med Mol Imaging 37:1943-9
Kannan, Pavitra; Brimacombe, Kyle R; Zoghbi, Sami S et al. (2010) N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier. Drug Metab Dispos 38:917-22

Showing the most recent 10 out of 73 publications