Treatment studies? We are currently engaged in testing the ability of transcranial direct current brain polarization to modulate frontal lobe activity. Ongoing studies in this area are on (1) emotion-based decision making and response to arousing stimuli and (2) enhancing verbal memory and other forms of learning.? ? Neurophysiological probe studies? We have successfully shown changes in the motor cortex response to transcranial magnetic stimulation that are linked to the expecting and receiving money reward. This is the first demonstration of reward related activity in the motor cortex and links the motor cortex conceptually with other frontal areas involved in response generation and selection. We will go on to test the dopamine contribution to this phenomenon by repeating the experiment in patients with Parkinson disease on and off medication.? ? Collaborative work? With support from a DARPA program on accelerated learning, we are collaborating with investigators at the MIND Institute at the University of New Mexico on using DC brain polarization to shorten the time required to attain behavioral and neuroimaging endpoints for expert status on threat recognition tasks.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Intramural Research (Z01)
Project #
1Z01NS002977-09
Application #
7594681
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2007
Total Cost
$534,990
Indirect Cost
City
State
Country
United States
Zip Code
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Morales, Oscar G; Henry, Michael E; Nobler, Mitchell S et al. (2005) Electroconvulsive therapy and repetitive transcranial magnetic stimulation in children and adolescents: a review and report of two cases of epilepsia partialis continua. Child Adolesc Psychiatr Clin N Am 14:193-210, viii-ix
Wassermann, Eric M; Grafman, Jordan (2005) Recharging cognition with DC brain polarization. Trends Cogn Sci 9:503-5

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