Abstract

The Section is the statistical and data management component of the Center for Cancer Research (CCR). The Section provides statistical leadership and data management consultation for major activities of the Center, and is involved in the design, conduct, monitoring, and statistical analyses of intramural and national multicenter clinical trials of experimental treatments for cancer, and intramural clinical trials for treatment of AIDS. The section provides a broad range of data analysis and consultation services to laboratories performing basic scientific research into the origin and growth mechanisms of cancer and AIDS. Other major collaborative efforts include studies to identify important prognostic and treatment selection factors, evaluate diagnostic procedures, develop improved staging systems, and assist investigators in the design, execution, and analyses of major in vitro drug testing studies. The Section develops and implements new statistical designs and biometric methods related to the development and evaluation of new cancer and AIDS treatments. The Section maintains a unified system for tracking basic information on all patients registered on CCR treatment protocols. Approximately 20% of the Section's activities are HIV-AIDS related.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01SC007202-24
Application #
7735378
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
24
Fiscal Year
2008
Total Cost
$698,024
Indirect Cost

  Institution

Name
National Cancer Institute Division of Clinical Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Lechleider, Robert J; Arlen, Philip M; Tsang, Kwong-Yok et al. (2008) Safety and immunologic response of a viral vaccine to prostate-specific antigen in combination with radiation therapy when metronomic-dose interleukin 2 is used as an adjuvant. Clin Cancer Res 14:5284-91
Gregorc, V; Hidalgo, M; Spreafico, A et al. (2008) Germline polymorphisms in EGFR and survival in patients with lung cancer receiving gefitinib. Clin Pharmacol Ther 83:477-84
Norton, Jeffrey A; Venzon, David J; Berna, Marc J et al. (2008) Prospective study of surgery for primary hyperparathyroidism (HPT) in multiple endocrine neoplasia-type 1 and Zollinger-Ellison syndrome: long-term outcome of a more virulent form of HPT. Ann Surg 247:501-10
Powell, Anathea C; Stratakis, Constantine A; Patronas, Nicholas J et al. (2008) Operative management of Cushing syndrome secondary to micronodular adrenal hyperplasia. Surgery 143:750-8
Sportes, Claude; Hakim, Frances T; Memon, Sarfraz A et al. (2008) Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets. J Exp Med 205:1701-14
Cecchinato, Valentina; Tryniszewska, Elzbieta; Ma, Zhong Min et al. (2008) Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection. J Immunol 180:5439-47
Sharifi, Nima; Hamada, Akinobu; Sissung, Tristan et al. (2008) A polymorphism in a transporter of testosterone is a determinant of androgen independence in prostate cancer. BJU Int 102:617-21
Gril, Brunilde; Palmieri, Diane; Bronder, Julie L et al. (2008) Effect of lapatinib on the outgrowth of metastatic breast cancer cells to the brain. J Natl Cancer Inst 100:1092-103
Patterson, L Jean; Beal, Jennifer; Demberg, Thorsten et al. (2008) Replicating adenovirus HIV/SIV recombinant priming alone or in combination with a gp140 protein boost results in significant control of viremia following a SHIV89.6P challenge in Mamu-A*01 negative rhesus macaques. Virology 374:322-37
Sissung, Tristan M; Baum, Caitlin E; Deeken, John et al. (2008) ABCB1 genetic variation influences the toxicity and clinical outcome of patients with androgen-independent prostate cancer treated with docetaxel. Clin Cancer Res 14:4543-9

Showing the most recent 10 out of 127 publications