Abstract

The causes and consequences of decline in muscle biomechanical quality with aging are unknown. Since it has been postulated that a large portion of age-related loss of mobility and disability with aging is linked with loss of muscle strength, identification of such causes is essential in order to develop therapeutic strategies that may effectively preserve physical disability with aging. This project entails a number of studies that scan a wide range of hypotheses concerning the origin of muscle quality and its consequence with aging. This discovery stage will be followed by more in dept studies that focus on the most promising lines of research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000995-03
Application #
9565906
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
Aging
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Vespasiani-Gentilucci, Umberto; De Vincentis, Antonio; Ferrucci, Luigi et al. (2018) Low Alanine Aminotransferase Levels in the Elderly Population: Frailty, Disability, Sarcopenia, and Reduced Survival. J Gerontol A Biol Sci Med Sci 73:925-930
Gonzalez-Freire, Marta; Moaddel, Ruin; Sun, Kai et al. (2018) Targeted Metabolomics Shows Low Plasma Lysophosphatidylcholine 18:2 Predicts Greater Decline of Gait Speed in Older Adults: The Baltimore Longitudinal Study of Aging. J Gerontol A Biol Sci Med Sci :
Martinez-Gomez, David; Bandinelli, Stefania; Del-Panta, Vieri et al. (2018) Three-Year Changes in Physical Activity and Subsequent Loss of Ability to Walk 400 m in Older Adults: The InCHIANTI Study. Am J Phys Med Rehabil 97:212-215
Osawa, Yusuke; Studenski, Stephanie A; Ferrucci, Luigi (2018) Knee extension rate of torque development and peak torque: associations with lower extremity function. J Cachexia Sarcopenia Muscle 9:530-539
Gonzalez-Freire, Marta; Scalzo, Paul; D'Agostino, Jarod et al. (2018) Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore Longitudinal Study of Aging. Aging Cell 17:
Tian, Qu; Osawa, Yusuke; Resnick, Susan M et al. (2018) Rate of muscle contraction is associated with cognition in women, not in men. J Gerontol A Biol Sci Med Sci :
Stenholm, Sari; Ferrucci, Luigi; Vahtera, Jussi et al. (2018) Natural Course of Frailty Components in People Who Develop Frailty Syndrome: Evidence From Two Cohort Studies. J Gerontol A Biol Sci Med Sci :
Jin, Yichen; Tanaka, Toshiko; Bandinelli, Stefania et al. (2017) Overall Cardiovascular Health Is Associated With All-Cause and Cardiovascular Disease Mortality Among Older Community-Dwelling Men and Women. J Aging Health 29:437-453
Zane, Ariel C; Reiter, David A; Shardell, Michelle et al. (2017) Muscle strength mediates the relationship between mitochondrial energetics and walking performance. Aging Cell 16:461-468
Chiles Shaffer, Nancy; Ferrucci, Luigi; Shardell, Michelle et al. (2017) Agreement and Predictive Validity Using Less-Conservative Foundation for the National Institutes of Health Sarcopenia Project Weakness Cutpoints. J Am Geriatr Soc 65:574-579

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