The causes and consequences of decline in muscle biomechanical quality with aging are unknown. Since it has been postulated that a large portion of age-related loss of mobility and disability with aging is linked to loss of muscle strength, identification of such causes is essential in order to develop therapeutic strategies that may effectively preserve physical ability with aging. This project entails a number of studies that scan a wide range of hypotheses concerning the origin of muscle quality and its consequences with aging. This discovery stage will be followed by more in depth studies that focus on the most promising lines of research.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Investigator-Initiated Intramural Research Projects (ZIA)
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National Institute on Aging
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Vespasiani-Gentilucci, Umberto; De Vincentis, Antonio; Ferrucci, Luigi et al. (2018) Low Alanine Aminotransferase Levels in the Elderly Population: Frailty, Disability, Sarcopenia, and Reduced Survival. J Gerontol A Biol Sci Med Sci 73:925-930
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