This project uses the NHANES 1999-2004 data on body composition to examine the prevalence of sarcopenia in the U.S. population. We created a new definition of non-sarcopenic adults based on data from normal weight persons aged 20-39 in the U.S. population and used it to explored the prevalence of sarcopenia in persons aged 40 and older. We are particularly interested in the presence of sarcopenia in men and women over age 70. We will consider how the definitions of sarcopenia and myosteatosis are affected by race, ethnicity or weight. It is unclear if one definition of sarcopenia based on body composition alone can describe the association of body composition with disability for very thin and very heavy individuals. This project aims to assist the American Geriatrics Society in creation of a working definition of sarcopenia for geriatric practice.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Investigator-Initiated Intramural Research Projects (ZIA)
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National Institute on Aging
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Fragala, Maren S; Dam, Thuy-Tien L; Barber, Vanessa et al. (2015) Strength and function response to clinical interventions of older women categorized by weakness and low lean mass using classifications from the Foundation for the National Institute of Health sarcopenia project. J Gerontol A Biol Sci Med Sci 70:202-9
McLean, Robert R; Shardell, Michelle D; Alley, Dawn E et al. (2014) Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: the foundation for the National Institutes of Health (FNIH) sarcopenia project. J Gerontol A Biol Sci Med Sci 69:576-83
Cawthon, Peggy M; Peters, Katherine W; Shardell, Michelle D et al. (2014) Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness. J Gerontol A Biol Sci Med Sci 69:567-75
Dam, Thuy-Tien; Peters, Katherine W; Fragala, Maren et al. (2014) An evidence-based comparison of operational criteria for the presence of sarcopenia. J Gerontol A Biol Sci Med Sci 69:584-90
Murphy, Rachel A; Ip, Edward H; Zhang, Qiang et al. (2014) Transition to sarcopenia and determinants of transitions in older adults: a population-based study. J Gerontol A Biol Sci Med Sci 69:751-8
Studenski, Stephanie A; Peters, Katherine W; Alley, Dawn E et al. (2014) The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci 69:547-58
Alley, Dawn E; Shardell, Michelle D; Peters, Katherine W et al. (2014) Grip strength cutpoints for the identification of clinically relevant weakness. J Gerontol A Biol Sci Med Sci 69:559-66
Leitzmann, Michael F; Moore, Steven C; Koster, Annemarie et al. (2011) Waist circumference as compared with body-mass index in predicting mortality from specific causes. PLoS One 6:e18582
Bankoski, Andrea; Harris, Tamara B; McClain, James J et al. (2011) Sedentary activity associated with metabolic syndrome independent of physical activity. Diabetes Care 34:497-503
Lang, T; Streeper, T; Cawthon, P et al. (2010) Sarcopenia: etiology, clinical consequences, intervention, and assessment. Osteoporos Int 21:543-59