Maintenance of independence in old age depends, in part, on lower extremity function. Lean mass and strength both contribute to lower extremity function. Although the term sarcopenia suggests that muscle mass is the key factor, interventions on strength alone, rather than on mass alone, have been more effective in reversing disability. This project is multifaceted and is conducted through collaboration with several extramural investigators. It includes work with the Sarcopenia Initiative with the NIH Foundation, analysis of factors that might accelerate or prevent loss of lean mass, and projects focused on hypertrophy of muscle and change in fatty infiltration with interventions.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Investigator-Initiated Intramural Research Projects (ZIA)
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National Institute on Aging
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Fragala, Maren S; Dam, Thuy-Tien L; Barber, Vanessa et al. (2015) Strength and function response to clinical interventions of older women categorized by weakness and low lean mass using classifications from the Foundation for the National Institute of Health sarcopenia project. J Gerontol A Biol Sci Med Sci 70:202-9
McLean, Robert R; Shardell, Michelle D; Alley, Dawn E et al. (2014) Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: the foundation for the National Institutes of Health (FNIH) sarcopenia project. J Gerontol A Biol Sci Med Sci 69:576-83
Cawthon, Peggy M; Peters, Katherine W; Shardell, Michelle D et al. (2014) Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness. J Gerontol A Biol Sci Med Sci 69:567-75
Dam, Thuy-Tien; Peters, Katherine W; Fragala, Maren et al. (2014) An evidence-based comparison of operational criteria for the presence of sarcopenia. J Gerontol A Biol Sci Med Sci 69:584-90
Murphy, Rachel A; Ip, Edward H; Zhang, Qiang et al. (2014) Transition to sarcopenia and determinants of transitions in older adults: a population-based study. J Gerontol A Biol Sci Med Sci 69:751-8
Studenski, Stephanie A; Peters, Katherine W; Alley, Dawn E et al. (2014) The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci 69:547-58
Alley, Dawn E; Shardell, Michelle D; Peters, Katherine W et al. (2014) Grip strength cutpoints for the identification of clinically relevant weakness. J Gerontol A Biol Sci Med Sci 69:559-66
Leitzmann, Michael F; Moore, Steven C; Koster, Annemarie et al. (2011) Waist circumference as compared with body-mass index in predicting mortality from specific causes. PLoS One 6:e18582
Bankoski, Andrea; Harris, Tamara B; McClain, James J et al. (2011) Sedentary activity associated with metabolic syndrome independent of physical activity. Diabetes Care 34:497-503
Lang, T; Streeper, T; Cawthon, P et al. (2010) Sarcopenia: etiology, clinical consequences, intervention, and assessment. Osteoporos Int 21:543-59