Lyme disease is a multisystem illness caused by infection with the spirochete Borrelia burgdorferi and it is the leading vector-borne disease in the United States. Lyme disease is also common in Europe and also occurs in Russia, China and Japan. In humans, B. burgdorferi infection causes infection primarily in the skin, nervous system, heart and joints. Lyme disease can usually be treated successfully with antibiotic therapy, with the best results seen in patients with early disease. Unfortunately, some patients may not have a complete response to therapy. We currently have three clinical protocols studying patients with Lyme disease. Two protocols are natural history studies and serve as the basis for multiple lines of investigation. One protocol addresses patients with post Lyme disease syndrome. The other protocol allow for the study of patients with classical Lyme disease. A third protocol examines the host reponse in skin biopsies from patients with erythema migrans lesions using microarrays. Our work addresses 3 areas in Lyme disease: laboratory diagnosis, clinical manifestations and immunological responses to B. burgdorferi. We also have a protocol to investigate the cause of Southern Tick-Associated Rash Illness (STARI), in collaboration with the CDC. STARI is a rash similar to the rash of Lyme disease that occurs in persons residing in southeastern and south-central states and is associated with the bite of the lone star tick, Amblyomma americanum.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Zip Code
Turk, Siu-Ping; Williams, Carla; Marques, Adriana (2018) Xenodiagnosis Using Ixodes scapularis Larval Ticks in Humans. Methods Mol Biol 1690:337-346
Bernard, Quentin; Smith, Alexis A; Yang, Xiuli et al. (2018) Plasticity in early immune evasion strategies of a bacterial pathogen. Proc Natl Acad Sci U S A 115:E3788-E3797
Branda, John A; Body, Barbara A; Boyle, Jeff et al. (2018) Advances in Serodiagnostic Testing for Lyme Disease Are at Hand. Clin Infect Dis 66:1133-1139
Uhde, Melanie; Indart, Alyssa; Fallon, Brian A et al. (2018) C-Reactive Protein Response in Patients With Post-Treatment Lyme Disease Symptoms Versus Those With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Clin Infect Dis 67:1309-1310
Marques, Adriana R (2018) Revisiting the Lyme Disease Serodiagnostic Algorithm: the Momentum Gathers. J Clin Microbiol 56:
Tokarz, Rafal; Mishra, Nischay; Tagliafierro, Teresa et al. (2018) A multiplex serologic platform for diagnosis of tick-borne diseases. Sci Rep 8:3158
Uhde, Melanie; Ajamian, Mary; Wormser, Gary P et al. (2017) Reply to Naktin. Clin Infect Dis 64:1145-1146
Pavletic, Adriana J; Marques, Adriana R (2017) Early Disseminated Lyme Disease Causing False Positive Serology for Primary Epstein-Barr Virus Infection - Report of 2 Cases. Clin Infect Dis :
Marques, Adriana R; Yang, Xiuli; Smith, Alexis A et al. (2017) Citrate Anticoagulant Improves the Sensitivity of Borreliella (Borrelia) burgdorferi Plasma Culture. J Clin Microbiol 55:3297-3299
Marques, Adriana; Schwartz, Ira; Wormser, Gary P et al. (2017) Transcriptome Assessment of Erythema Migrans Skin Lesions in Patients With Early Lyme Disease Reveals Predominant Interferon Signaling. J Infect Dis 217:158-167

Showing the most recent 10 out of 36 publications