Abstract

In schistosomiasis and other diseases associated with type-2 immunity, the pathology resulting from chronic infection or chronic allergen exposure is predominantly induced by the host immune response. The chronic type-2 immune response eventually triggers significant fibrosis, which is the primary cause of morbidity and mortality in many chronic infectious and inflammatory diseases. Our work is focused on elucidating the mechanisms of granulomatous inflammation, fibrosis, portal hypertension, and death following infection with S. mansoni and to devise novel strategies to slow or reverse the progression of liver fibrosis. Over the preceding 10 months, our work has focused on finishing up remaining projects as the Wynn lab was slated to close June 30, 2018. Two submitted papers are currently under revision.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI000829-21
Application #
9786337
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
21
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Palacios-Macapagal, Daphne; Connor, Jane; Mustelin, Tomas et al. (2017) Cutting Edge: Eosinophils Undergo Caspase-1-Mediated Pyroptosis in Response to Necrotic Liver Cells. J Immunol 199:847-853
Van de Velde, Lee-Ann; Subramanian, Chitra; Smith, Amber M et al. (2017) T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions. J Biol Chem 292:15-30
Borthwick, L A; Barron, L; Hart, K M et al. (2016) Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis. Mucosal Immunol 9:38-55
Vannella, Kevin M; Ramalingam, Thirumalai R; Hart, Kevin M et al. (2016) Acidic chitinase primes the protective immune response to gastrointestinal nematodes. Nat Immunol 17:538-44
Soucy, Katie; Fairhurst, Rick M; Lynn, Geoffrey M et al. (2016) Breaking the Mold: Partnering with the National Institutes of Health Intramural Research Program to Accelerate PhD Training. Trends Immunol 37:813-815
Sun, Rex; Urban Jr, Joseph F; Notari, Luigi et al. (2016) Interleukin-13 Receptor ?1-Dependent Responses in the Intestine Are Critical to Parasite Clearance. Infect Immun 84:1032-1044
Ramalingam, Thirumalai R; Gieseck, Richard L; Acciani, Thomas H et al. (2016) Enhanced protection from fibrosis and inflammation in the combined absence of IL-13 and IFN-?. J Pathol 239:344-54
Gieseck 3rd, Richard L; Ramalingam, Thirumalai R; Hart, Kevin M et al. (2016) Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis. Immunity 45:145-58
Wynn, Thomas A; Vannella, Kevin M (2016) Macrophages in Tissue Repair, Regeneration, and Fibrosis. Immunity 44:450-462
Tacke, Frank; Wynn, Thomas A (2015) Biomarker and Therapeutic Potential of CSF1 in Acute Liver Failure. Gastroenterology 149:1675-8

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