Abstract

Our program's multidisciplinary research activities are carried out at several NIH-sponsored laboratories and clinics in malaria-endemic regions of Mali and Cambodia, where we investigate four subject areas: (1) the molecular mechanism by which sickle-cell trait (hemoglobin S) confers protection to Plasmodium falciparum malaria; (2) the parasite and host factors that influence the rate of P. falciparum parasite clearance in patients treated with the antimalarial drug artemisinin; (3) the molecular mechanisms of P. falciparum resistance to frontline antimalarial drugs, including artemisinin and piperaquine; and (4) the role of Anopheles mosquito vectors in the spread of multidrug-resistant P. falciparum parasites. In each of these areas we seek research advances that improve our knowledge of disease processes and drug-resistance mechanisms in patients with malaria, with the ultimate goal of developing new antimalarial therapeutics, vaccines, and transmission-blocking interventions to prevent infection, illness, and death.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI001000-10
Application #
9354813
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Mukherjee, Angana; Bopp, Selina; Magistrado, Pamela et al. (2017) Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia. Malar J 16:195
Morita, Masayuki; Takashima, Eizo; Ito, Daisuke et al. (2017) Immunoscreening of Plasmodium falciparum proteins expressed in a wheat germ cell-free system reveals a novel malaria vaccine candidate. Sci Rep 7:46086
Ataide, Ricardo; Ashley, Elizabeth A; Powell, Rosanna et al. (2017) Host immunity to Plasmodium falciparum and the assessment of emerging artemisinin resistance in a multinational cohort. Proc Natl Acad Sci U S A 114:3515-3520
Amato, Roberto; Lim, Pharath; Miotto, Olivo et al. (2017) Genetic markers associated with dihydroartemisinin-piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype-phenotype association study. Lancet Infect Dis 17:164-173
Hamilton, William L; Claessens, Antoine; Otto, Thomas D et al. (2017) Extreme mutation bias and high AT content in Plasmodium falciparum. Nucleic Acids Res 45:1889-1901
Tétard, Marilou; Milet, Jacqueline; Dechavanne, Sébastien et al. (2017) Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria. Sci Rep 7:1414
Adomako-Ankomah, Yaw; Chenoweth, Matthew S; Durfee, Katelyn et al. (2017) High Plasmodium falciparum longitudinal prevalence is associated with high multiclonality and reduced clinical malaria risk in a seasonal transmission area of Mali. PLoS One 12:e0170948
Longley, Rhea J; França, Camila T; White, Michael T et al. (2017) Asymptomatic Plasmodium vivax infections induce robust IgG responses to multiple blood-stage proteins in a low-transmission region of western Thailand. Malar J 16:178
Fairhurst, Rick M; Dondorp, Arjen M (2016) Artemisinin-Resistant Plasmodium falciparum Malaria. Microbiol Spectr 4:
Pearson, Richard D; Amato, Roberto; Auburn, Sarah et al. (2016) Genomic analysis of local variation and recent evolution in Plasmodium vivax. Nat Genet 48:959-64

Showing the most recent 10 out of 94 publications