Abstract

Our goal is to investigate the miRNA profiles of prostate tumors and the normal epithelium to evaluate if there are differences in specific miRNA expression patterns of tumors with different grades of differentiation and different biological beavior. Prostate cancers will be manually microdissected to obtain pure populations of tumor cells as well as available normal epithelium distant to the tumor area. Histological features such as Gleason score, presence of perineural, lymphatic invasion, extracapsular or seminal vesicle invasion were also evaluated and recorded for each case. Differentially expressed miRNAs will be defined as those with a two-fold change (up or down) and a p value <0.05. Different miRNAs expression profiles will include comparison between the low grade tumors (Gleason score 6 and 7) vs. high grade (Gleason score 8 and 9) lesions. Then, each tumor group will be compared with their respective group of normal epithelium.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011406-01
Application #
8349529
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2011
Total Cost
$195,077
Indirect Cost

  Institution

Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Hoang, Uyen N; Mojdeh Mirmomen, S; Meirelles, Osorio et al. (2018) Assessment of multiphasic contrast-enhanced MR textures in differentiating small renal mass subtypes. Abdom Radiol (NY) :
Navaei, Amir Hassan; Walter, Beatriz A; Moreno, Vanessa et al. (2017) Correlation between ERG Fusion Protein and Androgen Receptor Expression by Immunohistochemistry in Prostate, Possible Role in Diagnosis and Therapy. J Cancer 8:2604-2613
Greer, Matthew D; Brown, Anna M; Shih, Joanna H et al. (2016) Accuracy and agreement of PIRADSv2 for prostate cancer mpMRI: A multireader study. J Magn Reson Imaging :
Turkbey, Baris; Lindenberg, Maria L; Adler, Stephen et al. (2016) PET/CT imaging of renal cell carcinoma with (18)F-VM4-037: a phase II pilot study. Abdom Radiol (NY) 41:109-18
Muthigi, Akhil; Sidana, Abhinav; George, Arvin K et al. (2016) Midline lesions of the prostate: role of MRI/TRUS fusion biopsy and implications in Gleason risk stratification. Int Urol Nephrol 48:1445-52
Mertan, Francesca V; Greer, Matthew D; Borofsky, Sam et al. (2016) Multiparametric Magnetic Resonance Imaging of Recurrent Prostate Cancer. Top Magn Reson Imaging 25:139-47
Bi, Mark; Zhao, Siming; Said, Jonathan W et al. (2016) Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma. Proc Natl Acad Sci U S A 113:2170-5
Elbuluk, Osama; Muradyan, Naira; Shih, Joanna et al. (2016) Differentiating Transition Zone Cancers From Benign Prostatic Hyperplasia by Quantitative Multiparametric Magnetic Resonance Imaging. J Comput Assist Tomogr 40:218-24
Fascelli, Michele; Rais-Bahrami, Soroush; Sankineni, Sandeep et al. (2016) Combined Biparametric Prostate Magnetic Resonance Imaging and Prostate-specific Antigen in the Detection of Prostate Cancer: A Validation Study in a Biopsy-naive Patient Population. Urology 88:125-34
Siddiqui, M Minhaj; George, Arvin K; Rubin, Rachel et al. (2016) Efficiency of Prostate Cancer Diagnosis by MR/Ultrasound Fusion-Guided Biopsy vs Standard Extended-Sextant Biopsy for MR-Visible Lesions. J Natl Cancer Inst 108:

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