miRNA profiling of prostate cancer in young and older male patients

Merino, Maria

Abstract

Our goal is to investigate the miRNA profiles of prostate tumors occurring in young patients and compare with the miRNA expression of prostate cancers occurring in the elderly patients. We will evaluate if there are differences in specific miRNA expression patterns of tumors with different grades of differentiation and different biological behavior. Prostate cancers will be manually microdissected to obtain pure populations of tumor cells as well as available normal epithelium distant to the tumor area. Histological features such as Gleason score, presence of perineural, lymphatic invasion, extracapsular or seminal vesicle invasion were also evaluated and recorded for each case. Differentially expressed miRNAs will be defined as those with a two-fold change (up or down) and a p value 0.05. Different miRNAs expression profiles will include comparison between the low grade tumors (Gleason score 6 and 7) vs. high grade (Gleason score 8 and 9) lesions. Then, each tumor group will be compared with their respective group of normal epithelium. Patients of younger 40-50 years and older will be selected for the study.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIABC011406-08
• Application #: 9779889
• Support Year: 8
• Fiscal Year: 2018

Institution

• Name: Basic Sciences

Publications

Hoang, Uyen N; Mojdeh Mirmomen, S; Meirelles, Osorio et al. (2018) Assessment of multiphasic contrast-enhanced MR textures in differentiating small renal mass subtypes. Abdom Radiol (NY) :

Navaei, Amir Hassan; Walter, Beatriz A; Moreno, Vanessa et al. (2017) Correlation between ERG Fusion Protein and Androgen Receptor Expression by Immunohistochemistry in Prostate, Possible Role in Diagnosis and Therapy. J Cancer 8:2604-2613

Mertan, Francesca V; Greer, Matthew D; Borofsky, Sam et al. (2016) Multiparametric Magnetic Resonance Imaging of Recurrent Prostate Cancer. Top Magn Reson Imaging 25:139-47

Bi, Mark; Zhao, Siming; Said, Jonathan W et al. (2016) Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma. Proc Natl Acad Sci U S A 113:2170-5

Elbuluk, Osama; Muradyan, Naira; Shih, Joanna et al. (2016) Differentiating Transition Zone Cancers From Benign Prostatic Hyperplasia by Quantitative Multiparametric Magnetic Resonance Imaging. J Comput Assist Tomogr 40:218-24

Fascelli, Michele; Rais-Bahrami, Soroush; Sankineni, Sandeep et al. (2016) Combined Biparametric Prostate Magnetic Resonance Imaging and Prostate-specific Antigen in the Detection of Prostate Cancer: A Validation Study in a Biopsy-naive Patient Population. Urology 88:125-34

Siddiqui, M Minhaj; George, Arvin K; Rubin, Rachel et al. (2016) Efficiency of Prostate Cancer Diagnosis by MR/Ultrasound Fusion-Guided Biopsy vs Standard Extended-Sextant Biopsy for MR-Visible Lesions. J Natl Cancer Inst 108:

Mertan, Francesca V; Greer, Matthew D; Shih, Joanna H et al. (2016) Prospective Evaluation of the Prostate Imaging Reporting and Data System Version 2 for Prostate Cancer Detection. J Urol 196:690-6

Greer, Matthew D; Brown, Anna M; Shih, Joanna H et al. (2016) Accuracy and agreement of PIRADSv2 for prostate cancer mpMRI: A multireader study. J Magn Reson Imaging :

Turkbey, Baris; Lindenberg, Maria L; Adler, Stephen et al. (2016) PET/CT imaging of renal cell carcinoma with (18)F-VM4-037: a phase II pilot study. Abdom Radiol (NY) 41:109-18