Abstract

The goal of this project is to implement systematically different skin-directed and systemic modalities in healthy volunteers and patients with skin disorders to explore how human microbial communities are altered. In addition to identifying changes in host microbial communities, we have been working to develop ways to study the potential effects of microbiome alterations on host health and disease. In fiscal year 2014, we have continued to recruit patients and healthy volunteers to participate in our interventional protocols. Additionally, we are working with collaborators who have interventional protocols to investigate the composition of host microbial communities prior to and after implementation of systemic or topical interventions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011558-01
Application #
8938194
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost

  Institution

Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Kennedy, Elizabeth A; Connolly, Jennifer; Hourihane, Jonathan O'B et al. (2017) Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year. J Allergy Clin Immunol 139:166-172
Jo, Jay-Hyun; Kennedy, Elizabeth A; Kong, Heidi H (2017) Topographical and physiological differences of the skin mycobiome in health and disease. Virulence 8:324-333
Kong, Heidi H; Andersson, Björn; Clavel, Thomas et al. (2017) Performing Skin Microbiome Research: A Method to the Madness. J Invest Dermatol 137:561-568
Kong, Heidi H; Segre, Julia A (2017) The Molecular Revolution in Cutaneous Biology: Investigating the Skin Microbiome. J Invest Dermatol 137:e119-e122
Kong, Heidi H; Morris, Alison (2017) The emerging importance and challenges of the human mycobiome. Virulence 8:310-312
Byrd, Allyson L; Deming, Clay; Cassidy, Sara K B et al. (2017) Staphylococcus aureus and Staphylococcus epidermidis strain diversity underlying pediatric atopic dermatitis. Sci Transl Med 9:
Oh, Julia; Byrd, Allyson L; Park, Morgan et al. (2016) Temporal Stability of the Human Skin Microbiome. Cell 165:854-66
Jo, Jay-Hyun; Deming, Clay; Kennedy, Elizabeth A et al. (2016) Diverse Human Skin Fungal Communities in Children Converge in Adulthood. J Invest Dermatol 136:2356-2363
Jo, Jay-Hyun; Kennedy, Elizabeth A; Kong, Heidi H (2016) Research Techniques Made Simple: Bacterial 16S Ribosomal RNA Gene Sequencing in Cutaneous Research. J Invest Dermatol 136:e23-e27
Tsai, Yu-Chih; Conlan, Sean; Deming, Clayton et al. (2016) Resolving the Complexity of Human Skin Metagenomes Using Single-Molecule Sequencing. MBio 7:e01948-15

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