Abstract

The goal of this project is to implement systematically different skin-directed and systemic modalities in healthy volunteers and patients to explore how human microbial communities are altered. In addition to identifying changes in host microbial communities, we have been working to develop ways to study the potential effects of microbiome alterations on host health and disease. In the last fiscal year, we have continued to recruit patients and healthy volunteers to participate and to provide biospecimens. Additionally, we are working with collaborators who have interventional protocols to investigate the composition of host microbial communities prior to and after implementation of systemic or topical interventions. These include studies of immunotherapy treatments in oncology patients and antimicrobials in human subjects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011558-05
Application #
9779958
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Jo, Jay-Hyun; Kennedy, Elizabeth A; Kong, Heidi H (2017) Topographical and physiological differences of the skin mycobiome in health and disease. Virulence 8:324-333
Kong, Heidi H; Andersson, Björn; Clavel, Thomas et al. (2017) Performing Skin Microbiome Research: A Method to the Madness. J Invest Dermatol 137:561-568
Kong, Heidi H; Segre, Julia A (2017) The Molecular Revolution in Cutaneous Biology: Investigating the Skin Microbiome. J Invest Dermatol 137:e119-e122
Kong, Heidi H; Morris, Alison (2017) The emerging importance and challenges of the human mycobiome. Virulence 8:310-312
Byrd, Allyson L; Deming, Clay; Cassidy, Sara K B et al. (2017) Staphylococcus aureus and Staphylococcus epidermidis strain diversity underlying pediatric atopic dermatitis. Sci Transl Med 9:
Kennedy, Elizabeth A; Connolly, Jennifer; Hourihane, Jonathan O'B et al. (2017) Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year. J Allergy Clin Immunol 139:166-172
Tsai, Yu-Chih; Conlan, Sean; Deming, Clayton et al. (2016) Resolving the Complexity of Human Skin Metagenomes Using Single-Molecule Sequencing. MBio 7:e01948-15
Kong, Heidi H (2016) Details Matter: Designing Skin Microbiome Studies. J Invest Dermatol 136:900-902
Ferre, Elise M N; Rose, Stacey R; Rosenzweig, Sergio D et al. (2016) Redefined clinical features and diagnostic criteria in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. JCI Insight 1:
Oh, Julia; Byrd, Allyson L; Park, Morgan et al. (2016) Temporal Stability of the Human Skin Microbiome. Cell 165:854-66

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